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                         June 5, 2024

       Paul E. Mann
       Executive Chairman and Chief Executive Officer
       ASP Isotopes Inc.
       1101 Pennsylvania Avenue NW, Suite 300
       Washington, DC 20004

                                                        Re: ASP Isotopes Inc.
                                                            Registration
Statement on Form S-3
                                                            Filed May 31, 2024
                                                            File No. 333-279857

       Dear Paul E. Mann:

              This is to advise you that we have not reviewed and will not
review your registration
       statement.

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact Abby
Adams at 202-551-6902 with any questions.




                         Sincerely,


                         Division of Corporation Finance

                         Office of Industrial Applications and

                         Services