United States securities and exchange commission logo June 28, 2024 Paul Mann Chief Executive Officer ASP Isotopes Inc. 1101 Pennsylvania Avenue NW, Suite 300 Washington, DC 20004 Re: ASP Isotopes Inc. Form 10-K for the Fiscal Year Ended December 31, 2023 File No. 001-41555 Dear Paul Mann: We have limited our review of your filing to the financial statements and related disclosures and have the following comments. Please respond to this letter within ten business days by providing the requested information or advise us as soon as possible when you will respond. If you do not believe a comment applies to your facts and circumstances, please tell us why in your response. After reviewing your response to this letter, we may have additional comments. Form 10-K for the Fiscal Year Ended December 31, 2023 Consolidated Financial Statements Note 11. Acquisitions, page 79 1. For the acquisition of PET Labs Pharmaceuticals, we see that goodwill arising from the acquisition was attributable mainly to certain existing doctor and service center relationships, which are not identifiable as a separate intangible asset, along with buyer specific synergies expected to arise from the acquisition. Please tell us why the amounts related to existing doctor and service center relationships was not recorded as a separate intangible asset in accordance with ASC 805-20-25-10. 2. We see that ASP Rentals is considered a variable interest entity. Please revise future filings to provide the disclosures required by ASC 810-10-50-2AA through AC, as well as 50-3, including the judgments and assumptions you made in determining that ASP Rentals is a VIE and you are the primary beneficiary. Please also tell us where you considered the disclosure requirements of ASC 810-10-45-25. In your response, please provide us with a copy of your proposed revised disclosure. Paul Mann ASP Isotopes Inc. June 28, 2024 Page 2 Item 9A. Controls and Procedures Management's Annual Report on Internal Controls Over Financial Reporting, page 88 3. We see that you concluded your internal controls over financial reporting were effective at December 31, 2023. Please tell us how you arrived at such a determination given your disclosure controls and procedures were not effective due to material weaknesses identified in your internal control over financial reporting. Refer to SEC Release No. 33- 8238. In closing, we remind you that the company and its management are responsible for the accuracy and adequacy of their disclosures, notwithstanding any review, comments, action or absence of action by the staff. Please contact Kristin Lochhead at 202-551-3664 or Li Xiao at 202-551-4391 with any questions. Sincerely, FirstName LastNamePaul Mann Division of Corporation Finance Comapany NameASP Isotopes Inc. Office of Industrial Applications and June 28, 2024 Page 2 Services FirstName LastName