ASP Isotopes Inc.

601 Pennsylvania Avenue NW

South Building, Suite 900

Washington, DC 20004

May 27, 2025

VIA EDGAR

Securities and Exchange Commission

Division of Corporation Finance

100 F Street, N.E.

Washington, D.C. 20549

Attention: Robert Augustin

Re:	ASP Isotopes Inc. Registration Statement on Form S-3
	File No. 333-286860
	Acceleration Request
	Requested Date: Friday, May 30, 2025
	Requested Time: 4:00 P.M. Eastern Time

Ladies and Gentlemen:

Pursuant to Rule 461 under the Securities Act of 1933, as amended, ASP Isotopes Inc. hereby requests that the Securities and Exchange Commission accelerate the effectiveness of the above-referenced Registration Statement to 4:00 p.m., Eastern Time, on May 30, 2025, or as soon thereafter as practicable.

Please confirm once the Registration Statement has been declared effective by calling Donald Ainscow of Blank Rome LLP at (972) 850-1474. Please also contact him should you have any questions.

	Very truly yours,   ASP ISOTOPES INC.
	/s/ Paul Mann
	Paul Mann
	Chief Executive Officer

cc:	Donald Ainscow, Esq.
	Blank Rome LLP